邓恒为

博士，副教授、博士生导师

个人简介：

中山大学理学博士、博士后，海南自贸港 D 类人才，中国-东盟海水养殖技术“一带一路”联合实验室国际合作科技特派员。主要从事海洋动物分子免疫学及海洋生物病原分子生物学的研究。主持国家自然科学基金 2 项、广东省自然科学基金 1 项、海南大学启动基金 1项及福建省重点实验室开发课题 1 项，参与多项国家自然科学基金项目。发表论文 25 篇，其中 SCI 论文 20 篇，申请专利 2 项。

研究方向：

1. 甲壳动物抗病毒免疫分子机制

2. 水生动物先天性免疫调控机制

3. 病毒功能基因、致病机理及其与宿主的相互作用

研究项目：

1. 国自然地区科学基金，32260924，拟穴青蟹 SOCS2 介导的 JAK/STAT 通路负反馈环路及其对机体免疫稳态调控的分子机制，2023/01-2026/12，主持

2. 国自然青年科学基金，32002440，拟穴青蟹干扰素调节因子调控干扰素诱导基因ISG12 抗病毒的分子机制，2021/01-2023/12，主持

3. 农业农村部农业产业融合发展项目，对虾种资资源引进中转示范基地，2024/06-2026/09，主持

4. 广东省自然科学基金面上项目，2022A1515010958，拟穴青蟹 SOCS2 负反馈调控JAK/STAT 通路参与抗病毒免疫反应，2022/01-2024/12，主持5. 海南大学科研启动项目，拟穴青蟹干扰素诱导基因 IFI27L2 抗病毒的分子机制，2022/02-2027/02，主持

6. 水产动物疫病防控与健康养殖全国重点实验室开放课题，2024SKLBC-KF04，黄芩苷通过抑制 β-溶血活性防控无乳链球菌的机制研究，2025/01-2026/12，主持

7. 福建省海洋渔业资源与生态环境重点实验室课题，JAK-STAT 通路调控拟穴青蟹免疫稳态的分子机制及抗病毒效应，2023/10-2025/10，主持

8. 国家自然科学基金面上项目，32073004，p38 MAPK 信号通路调控凡纳滨对虾血淋巴透明细胞吞噬功能活化的分子机制，2021/01-2024/12，参与

9. 国家自然科学基金面上项目，31672677，青蟹呼肠孤病毒（MCRV）与青蟹双顺反子病毒（MCDV）共感染及相互影响机制，2017/01-2020/12，参与

代表论文：

1. Hengwei Deng, Danrong Xian, Taixin Lian, Mingyu He, Jingjing Li, Xiaopeng Xu, Zhixun Guo, Jianguo He*, Shaoping Weng*, A Dicer2 from Scylla paramamosain activates JAK/STAT signaling pathway to restrain mud crab reovirus, Developmental and Comparative Immunology, 127(2022)104267.

2. Hengwei Deng, Yeyu Li, Jinling Li, Wenjie Shen, Qiankang Chen, Shaoping Weng, Jianguo He, Xiaopeng Xu*, Neomycin inhibits Megalocytivirus infection in fish by antagonizing the increase of intracellular reduced glutathione, Fish & Shellfish Immunology, 127(2022), 148-154.

3. Hengwei Deng, Lei Hu, Jingjing Li, Wenyan Yan, Enhui Song, Mingqing Kuang,Shanshan Liu, Jianguo He*, Shaoping Weng*, The NF-κB family member dorsal plays a role in immune response against Gram-positive bacterial infection in mud crab (Scylla paramamosain),Developmental and Comparative Immunology,106 (2020) 103581.

4. Hengwei Deng, Wenfeng Zhang, Jingjing Li, Jinling Li, Lei Hu, Wenyan Yan, Shanshan Liu, Jianguo He*, Shaoping Weng*, A signal transducers and activators of transcription (STAT) gene from Scylla paramamosain is involved in resistance against mud crab reovirus, Fish and Shellfish Immunology,94 (2019) 580-591.

5. Hengwei Deng, Xiaopeng Xu, Lei Hu, Jingjing Li, Dandan Zhou, Shanshan Liu, Panpan Luo, Jianguo He*, Shaoping Weng*, A janus kinase from Scylla paramamosain activates JAK/STAT signaling pathway to restrain mud crab reovirus, Fish and Shellfish Immunology,90 (2019) 275-287.6. Deng Hengwei, Li Zhongbao*, Dai Gang, Yuan Yi, Ning Yefeng, Shangguan Jingbo, Huang Yesheng. Isolation of new polymorphic microsatellite markers from the marbled rockfish Sebastiscus marmoratus. Genetics and molecular research, 14(2015): 758-762.

7. Wei-Liang Guo, Heng-Wei Deng, Fei Wang, Shi-Feng Wang, Zhi-Hong Zhong, Yun Sun, Xue-Fen Chen, Jin-Hua Wang, Yong-Can Zhou*. In vitro and in vivo screening of herbal extracts against Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus). Aquaculture 503 (2019) 412-421.

8. Jiefeng Gao# , Ran Geng# , Hengwei Deng, Hongliang Zuo, Shaoping Weng, Jianguo He*, Xiaopeng Xu*. A novel Forkhead box protein P (FoxP) from Litopenaeus vannamei plays a positive role in immune response. Frontiers in Immunology, 11(2020):593987.

9. Wenfeng Zhang, Hengwei Deng, Yuting Fu, Weixuan Fu, Shaoping Weng, Jianguo He, Chuanfu Dong*. Production and characterization of monoclonal antibodies against mandarinfish ranavirus and first identification of pyloric caecum as the major target tissue. Journal of Fish Diseases, 0(2022), 1-11.

10. Long Zhang, Kun Wu, Haoyang Li, Minwen Zhan, Sheng Wang, Enhui Song, Jian He,Xinyi He, Menghuang Xu, Hengwei Deng, Yingchun Su, Ziwei Liu, Zhuyue Yan, Zhuyue Yan,Peipei Tan, Mengyun He, Shaoping Weng, Wei Ge, Jianguo He*, Muhua Wang*.Vitellogenin receptor mediates heat adaptability of oocyte development in mud crabs and zebrafish. Nature Communications, 16(2025): 3722.

11. Shoujia Jiang# , Lijun Fu# , Zijian Gao, Hengwei Deng, Yong Zhang, Xinxin You, Qiong Shi, Danqi Lu*. Multi-Omics Study on the Molecular Mechanisms of Tetraodon Nigroviridis Resistance to Exogenous Vibrio Parahaemolyticus Infection. Frontiers in Marine Science. 9(2022):914028.

12. Linwei Yang, Ziang Wang, Ran Geng, Hengwei Deng, Shengwen Niu, Hongliang Zuo, Shaoping Weng, Jianguo He, Xiaopeng Xu. White Spot Syndrome Virus (WSSV) Inhibits Hippo Signaling and Activates Yki to Promote Its Infection in Penaeus vannamei. Microbiol Spectr. 11(2023):0236322.

15. 邓恒为,周永灿,郭伟良,等.抗哈氏弧菌中草药筛选及其活性成份提取工艺的优化[J].水产科学, 2013, 32 (5):249-255.

16. 胡蕾,邓恒为,李晶晶,刘姗姗,何建国,李海云,翁少萍.拟穴青蟹 Cactus 基因的 cDNA克隆、序列及生物学功能[J].水产学报,2020,44(01):21-32.

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